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Originally these epigenetic changes were believed to occur only during fetal development.

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A January storm has deposited half a foot of snow outside the picture windows lining his fourth-floor corner office at the Douglas Institute, a mental health affiliate of Mc Gill.

He has the rugged good looks and tousled salt-and-pepper hair of someone found on a ski slope — precisely where he plans to go this weekend. “I’ve always been interested in what makes people different from each other,” he says.

On the floor lies an arrangement of helium balloons in various stages of deflation. “The way we act, the way we behave — some people are optimistic, some are pessimistic. Evolution selects the variance that is most successful, but what produces the grist for the mill?

” Meaney pursued the question of individual differences by studying how the rearing habits of mother rats caused lifelong changes in their offspring.

Sometimes methyl groups attached to DNA thanks to changes in diet; other times, exposure to certain chemicals appeared to be the cause.

Szyf showed that correcting epigenetic changes with drugs could cure certain cancers in animals.

In a landmark 1997 paper in , he showed that natural variations in the amount of licking and grooming received during infancy had a direct effect on how stress hormones, including corticosterone, were expressed in adulthood.

The more licking as babies, the lower the stress hormones as grown-ups.

The bar was in Madrid, where the Cajal Institute, Spain’s oldest academic center for the study of neurobiology, was holding an international meeting.

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